Discusses how interpersonal ties may be facilitated among the lonely and socially isolated. A general framework for conceptualizing solutions to loneliness is presented, and specific interventions are discussed. Limitations of person-centered interventions are examined, and alternative interventions aimed at modifying features of social settings are suggested. Interventions that may be helpful even when it is not possible to improve deficient social relations are also considered. Ethical issues raised by interventions for loneliness and cultural values that may constrain their effectiveness are discussed.