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Improvement in reliability of probabilistic test of significant differences in GeneChip experiments
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
Short Title: Anal.Sci.
Format: Journal Article
Publication Date: Nov 30, 2003
Pages: 731 - 733
Sources ID: 30806
Notes: LR: 20131121; JID: 8511078; 0 (Enzyme Inhibitors); EC 2.7.11.13 (Protein Kinase C); NI40JAQ945 (Tetradecanoylphorbol Acetate); 2004/05/01 05:00 [pubmed]; 2005/02/11 09:00 [medline]; 2004/05/01 05:00 [entrez]; ppublish
Visibility: Public (group default)
Abstract: (Show)
A probabilistic test (FUMI theory) for GeneChip experiments has been proposed for selecting the genes which show significant differences in the gene expression levels between a single pair of treatment and control. This paper describes that the reliability of the judgment by the FUMI theory can be enhanced, when the selected genes are referred to biomolecular-functional networks of a commercial database. The genes judged as being differently expressed are grouped into a cluster in the biomolecular networks. It is also demonstrated that false positive genes have a trend in the networks to be isolated from each other, and also away from the clustered genes, since the false positive genes are randomly selected.