Improvement in reliability of probabilistic test of significant differences in GeneChip experiments
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
Short Title:
Anal.Sci.
Format:
Journal Article
Publication Date:
Nov 30, 2003
Pages:
731 - 733
Sources ID:
30806
Notes:
LR: 20131121; JID: 8511078; 0 (Enzyme Inhibitors); EC 2.7.11.13 (Protein Kinase C); NI40JAQ945 (Tetradecanoylphorbol Acetate); 2004/05/01 05:00 [pubmed]; 2005/02/11 09:00 [medline]; 2004/05/01 05:00 [entrez]; ppublish
Collection:
Yoga-Based Medical Interventions
Visibility:
Public (group default)
Abstract:
(Show)
A probabilistic test (FUMI theory) for GeneChip experiments has been proposed for selecting the genes which show significant differences in the gene expression levels between a single pair of treatment and control. This paper describes that the reliability of the judgment by the FUMI theory can be enhanced, when the selected genes are referred to biomolecular-functional networks of a commercial database. The genes judged as being differently expressed are grouped into a cluster in the biomolecular networks. It is also demonstrated that false positive genes have a trend in the networks to be isolated from each other, and also away from the clustered genes, since the false positive genes are randomly selected.