Purpose: Chronic musculoskeletal pain (CMSP) is associated with work stress and burn-out among registered dental hygienists, with prevalence estimates ranging between 64 to 93%. Complementary and alternative medicine (CAM) therapies can be helpful in managing CMSP. The purpose of this study was to determine if dental hygienists who use CAM have greater career satisfaction compared to conventional therapy (CT) users. Methods: ADHA members (n=2,431) in North Carolina (n=573) and California (n=1,858) were surveyed. Data were analyzed using univariate and bivariate analyses and logistic regression. Results: A response rate of 25.3% (n=617) was obtained, revealing that 76.5% (n=472) suffered from CMSP. The use of CAM or CT was reported among 80.7% (n=381) of dental hygienists with CMSP. CAM users reported greater overall health (79.3% vs. 54.0%, p<0.001), career satisfaction (59.2% vs. 39.0%, p<0.001) and were able to work the hours they wanted (69.8% vs. 64.0%, p<0.001) compared to CT users. Of those with CMSP, 36.4% (n=172) considered a career change and 13.0% (n=59) reported having left dental hygiene. Those with CMSP were less likely to recall that ergonomics were taught or reinforced during clinical training. Conclusion: CAM therapies may improve quality of life, reduce work disruptions and enhance career satisfaction for dental hygienists who suffer from CMSP. Ergonomics education may help reduce the number of hygienists who suffer from CMSP. Increased student awareness of CMSP risk is needed to reduce CMSP in the future by enhancing ergonomics education and incorporating CAM, such as yoga stretches, into the classroom and clinic routine.