The article presents the origin of the rGyud bzhi, a book of Tibetan medicine in reference to the views of Zurkharwa Lodro Gyalpo, a physician of the 16th century. Gyalpo stated that rGyud bzhi was expounded by Buddha who had epistemological explanations and reasoning. However, Gyalpo marks a break in his life when he turn to the party that supported that rGyud bzhi is an original Tibetan treatise.