3-Hydroxymethylglutaryl flavonol glycosides from a Mongolian and Tibetan medicine, Oxytropis racemosa
Chemical & Pharmaceutical Bulletin
Short Title: Chem. Pharm. Bull.
Format: Journal Article
Publication Date: 2010/12//
Pages: 1587 - 1590
Sources ID: 94761
Collection: Himalayan and Tibetan Medicine
Visibility: Public (group default)
Three new flavonol 3-O-glycosides, rhamnetin 3-O-[(S)-3-hydroxy-3-methyl-glutaroyl(1→6)]-β-D-glucopyranoside (1), rhamnocitrin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-β-D-glucopyranoside (2), and isorhamnetin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside (3), along with 13 known compounds, were isolated from Oxytropis racemosa TURCZ. Their structures were deduced by means of spectroscopic methods and chemical evidence. 2 and 6 showed cytotoxic activities against HCT-8 (IC₅₀ 6.38 µM) and A549 (IC₅₀ 5.20 µM), respectively.