We present findings on the (1) acceptability of Spiritual Self-Schema (3-S) therapy with Puerto Rican women and (2) fit with women's cultural, gender, literacy, clinical, and religious backgrounds. 3-S is a well-documented efficacious intervention for substance use and HIV risk behaviors. Participants were 13 urban, low-income Puerto Rican women in a residential treatment program in a large Northeastern city.Findings from therapy session videotapes, focus groups, and clinician memos indicate high acceptability and fit of 3-S therapy for Puerto Rican women. However, lack of fit in several areas indicates the need for modification of specific aspects of 3-S for Latinas.