ObjectiveWe examined whether prenatal mindfulness training was associated with lower depressive symptoms through 18‐months postpartum compared to treatment as usual (TAU). Method A controlled, quasi‐experimental trial compared prenatal mindfulness training (MMT) to TAU. We collected depressive symptom data at post‐intervention, 6‐, and 18‐months postpartum. Latent profile analysis identified depressive symptom profiles, and multinomial logistic regression examined whether treatment condition predicted profile. Results Three depressive symptom severity profiles emerged: none/minimal, mild, and moderate. Adjusting for relevant covariates, MMT participants were less likely than TAU participants to be in the moderate profile than the none/minimal profile (OR = 0.13, 95% CI = 0.03‐0.54, p = .005). Conclusions Prenatal mindfulness training may have benefits for depressive symptoms during the transition to parenthood.