Background: In this research effectiveness of mindfulness based cognitive therapy (MBCT) on depression, anxiety and somatic symptoms in asthma patients was studied. Asthma is a psychosomatic disorder that depression and anxiety were considered as a trigger or exacerbation factor for it. Methods: According to this matter MBCT was used for reducing depression and anxiety and somatic symptoms in asthma patients. For this purpose 26 female patients that were under medical treatment for 1 year at least in Isfahan were selected and assigned in two groups randomly (experimental group and control group). Two groups were tested (pre-test) by Beck Depression Inventory (BDI_II), Beck Anxiety Inventory (BAI) and Asthma Quality of Life Questionnaire (AQLQ). Experimental group received MBCT intervention for 8 sessions weekly for two hours and control group was registered in waiting list. After finishing the therapy the two groups were tested again (post-test). Data was analyzed by ANCOVA in spss21 program. Results: Results show that after MBCT intervention significantly depression, anxiety and somatic symptoms scores decreased in experimental group in comparison with control group (p<0/05). Conclusion: So it shows that MBCT can reduce level of anxiety and depression in asthma patient and then reduces somatic symptom in this patients.