The present research aims to study the effectiveness of mindfulness-based cognitive therapy (MBCT) on increasing resilience, and reducing depression anxiety and stress, in infertile couples. The statistical population consisted of all infertile couples referred to health centers in Mashhad in 2015. The sample size of the present study included 30 infertile husbands and wives (15 couples). The participants were selected using convenience sampling. Fifteen participants were placed in the test group and 15 placed in the control group. Having been selected and placed in the intended groups, the participants attended eight sessions of MBCT classes. The control group did not receive any intervention. The tools used in the study were Connor-Davidson Resilience Scale (2003) (CD-RIS) and Depression-Anxiety-Stress Scale (DASS-21). Analysis of covariance was used to analyze the data obtained. The findings showed a significant difference between the total resilience score mean as well as depression, anxiety, and stress mean of the test and control groups in the post-test. In general, based on the findings of the present study, one can say that MBCT has been proved to be effective in increasing infertile women’s resilience and reducing depression, anxiety, and stress.