Objective: An experiment was conducted to determine the effects of chanting the maha mantra on stress, depression, and the three gunas—sattva (enlightenment), rajas (passion), and tamas (inertia)—described in the Vedas as the basis of human psychology. Primary hypotheses of the study were that the maha mantra group would increase sattva and decrease stress, depression, rajas, and tamas significantly more than the other groups. Method: Participants were tested at pretest, posttest, and follow-up, with testing times separated by 4 weeks. Participants were randomly assigned to a maha mantra group, an alternate mantra (placebo) group, and a control group. Results: MANOVA results supported these hypotheses from pretest to posttest at p < .05 for all dependent variables except rajas. Conclusions: The authors suggest that the maha mantra has potential in addressing problems related to stress and depression and that it be considered as one possible component of a spiritual approach to social work practice.