The present study involved the examination of a theoretical model of the relationship between meditative prayer and intercultural competence with dispositional gratitude and differentiation of self as mediator variables. Results supported the proposed model. A significant total indirect effect was observed between meditative prayer and intercultural competence. Significant specific indirect effects were observed between meditative prayer and intercultural competence with differentiation of self as the mediator, and through both gratitude and differentiation of self in a multiple-mediated association. Discussion focused on the construct of meditative prayer as a mindfulness practice and the unifying mechanisms among variables within the proposed model.