Mindfulness-based approaches to clinical interventions are receiving increasing attention in psychiatric research. The article in this issue of JAMA Psychiatry by Kuyken et al is an importantmeta-analysis of mindfulness-based cognitive therapy(MBCT) in the prevention of depression relapse. This meta-analysis was conducted at the individual patient level and included 9 randomized clinical trials, with data available for 1258 patients who participated in studies in which MBCT was compared with at least 1 non-MBCT treatment. The findings indicate that MBCT produced a reduced risk of depressive relapse within a 60-week follow-up period compared with other active treatments. Mindfulness-based cognitive therapy was most effective for patients with greater depressive severity before treatment.