The recent diagnosis of the Anthropocene represents the public death of the modern understanding of Nature removed from society. It also challenges the modern science-politics settlement, where natural science speaks for a stable, objective Nature. This paper reviews recent efforts to develop ‘multinatural’ alternatives that provide an environmentalism that need not make recourse to Nature. Focusing on biodiversity conservation, the paper draws together work in the social and natural sciences to present an interdisciplinary biogeography for conservation in the Anthropocene. This approach is developed through an engagement with the critiques of neoliberal natures offered by political ecology.