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A new pyrrolizidine alkaloid and other constituents from the roots of Ligularia achyrotricha (Diels) Ling
PHYTOL Phytochemistry Letters
Format: Journal Article
Publication Year: 2012
Pages: 541 - 544
Source ID: shanti-sources-104861
Abstract: Graphical abstract:
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Highlights: ► Ligularia achyrotricha is a traditional Tibetan medicine. ► Ligulachyroine A, a new alkaloid was isolated from the roots of L. achyrotricha. ► Eleven known compounds were also isolated from this species. ► Ligulachyroine A exhibited moderate activity against HL-60 and SMMC-7721 cells.
Ligularia achyrotricha (Diels) Ling has been used as a traditional Tibetan herbal medicine. Ligulachyroine A (1), a new twelve-membered macrocyclic pyrrolizidine alkaloid with a ketonic group located at C-3 and an hydroxy group linked at C-8, was isolated from the roots of L. achyrotricha. It is particularly noteworthy that the structure of 1 rarely appears in any other naturally occurring twelve-membered macrocyclic pyrrolizidine alkaloid reported to date. Three known lignans (2-4) and eight known coniferyl and sinapyl alcohol derivatives (5-12) were also obtained in this species. Their structures were elucidated through a careful analysis of their IR, MS, and NMR spectra. Compound 1 exhibited moderate activity against HL-60 and SMMC-7721 cells.