Peripheral arterial occlusive disease (PAOD) is in about 90% of the cases caused by atherosclerosis. Since this can affect all arteries of the body, PAOD is considered an important indicator of cardiovascular events such as heart attack or stroke, and thus of the leading cause of death in the Western world. With the measurement of the ankle/brachial pressure index (ABI), a practicable method is available to diagnose the disease in routine practice. Besides lifestyle modifications, the mainstay of treatment of atherosclerosis includes also drug treatment of known risk factors. In case of a severe circulatory disorder with critical ischemia, a revascularization by angioplasty or surgical methods is imperative. If the walking distance is limited due to PAOD, we speak of intermittent claudication. Here, in addition to the interventional treatment (percutaneous transluminal angioplasty (PTA) / surgery), a conservative walking exercise can be performed. The supportive use of Padma 28 in the conservative treatment has a measurable effect with a significant extension of the maximum walking distance and poses an additive treatment option.