Self-compassion is an adaptive way of relating to the self when considering personal inadequacies or difficult life circumstances. However, prior research has only examined self-compassion among adults. The current study examined self-compassion among adolescents (N = 235; Mage = 15.2) and included a sample of young adults as a comparison group (N = 287; Mage = 21.1). Results indicated that self-compassion was strongly associated with well-being among adolescents as well as adults. In addition, family and cognitive factors were identified as predictors of individual differences in self-compassion. Finally, self-compassion was found to partially mediate the link between family/cognitive factors and well-being. Findings suggest that self-compassion may be an effective intervention target for teens suffering from negative self-views.