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Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli
BioMed Research International
Short Title: Biomed Res Int
Format: Journal Article
Publication Date: Nov 30, 2016
Pages: 2320932
Sources ID: 92371
Notes: Accession Number: 125343171; Wang, Tianhong 1 Yang, Jian 2 Chen, Xing 3 Zhao, Kehui 1 Wang, Jing 1 Zhang, Yi 1 Zhao, Jing 4 Ga, Yang 5; Affiliation:  1: School of National Medicine, Chengdu University of TCM, Chengdu, China  2: School of Pharmacy, Second Military Medical University, Shanghai, China  3: Department of Mathematics, Logistical Engineering University, Chongqing, China  4: Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China  5: Tibetan Traditional Medical College, Lhasa, China; Source Info: 9/26/2017, Vol. 2017, p1; Subject Term: PHYTOTHERAPY; Subject Term: RHEUMATOID arthritis treatment; Subject Term: ANTIRHEUMATIC agents; Subject Term: ANIMAL experimentation; Subject Term: BATHS; Subject Term: GENE expression; Subject Term: RATS; Subject Term: SYSTEM analysis; Subject Term: THERAPEUTIC use; Subject Term: TIBET (China); NAICS/Industry Codes: 112990 All Other Animal Production; Number of Pages: 10p; Document Type: Article
Visibility: Public (group default)
Abstract: (Show)
In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK's anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.