This paper is intended to serve as a traditional Tibetan medical response to advancements in basic longevity research, with particular attention to current models of caloric restriction. This is a complicated task, as Tibetan medicine traditionally approaches dietary modification from a radically different perspective, and relies upon a complex model of health and balance in the treatment and prevention of disease. This paper offers a brief overview of the traditional Tibetan medicine (TTM) model and suggests potential areas for collaborative research on dietary modification.