Backgroundand purpose: The stress and systemic lupus erythematosus (SLE) are intertwined and affecting each other. This pilot study evaluated the mindfulness-based cognitive therapy (MBCT) in Korean patients with SLE. Materials and methods The Korean version of the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Satisfaction with Life Scale (SWLS), and Perceived Stress Scale (PSS) were evaluated for the effect of the MBCT in 25 patients. Results The BDI-II, BAI, SWLS, and PSS before the MBCT were 24.2 ± 10.6, 19.1 ± 9.7, 14.7 ± 6.5, and 20.4 ± 3.8, respectively. Eighteen patients completed the MBCT. After the MBCT, BDI-II, BAI, and PSS improved to 17.4 ± 13.0 (p < 0.01), 13.4 ± 7.7 (p = 0.04), and 17.9 ± 4.6 (p = 0.04), respectively. However, SWLS and SLE disease activity did not. Conclusion The MBCT could reduce the anxiety, depression, and stress but not SLE disease activity.