Objectives: Mindfulness training may help seniors successfully manage the physical and psychological challenges of aging in a manner that reduces distress and promotes vitality. The purpose of this retrospective analysis is to evaluate the impact of mindfulness-based stress reduction (MBSR) training on mood states in older adults. Methods: The authors identified 141 older adults (>60 years) who completed MBSR training. All participants completed the Profile of Mood States-Short Form (POMS-SF) at baseline and following 8 weeks of MBSR. Using paired t tests, the authors evaluated changes in mood following training in MBSR. In a subset analysis, the authors further examined the impact of MBSR training in individuals with the highest scores on depression and anxiety. Primary reasons cited for MBSR enrollment are also reported. Results: Overall emotional distress and all sub-scale mood measurements improved significantly following MBSR training. MBSR training resulted in >50% reduction in the number of older people reporting clinically significant depression and anxiety. Most enrolled in MBSR training to improve stress management skills. Discussion: MBSR training is a promising, group-based intervention for decreasing psychological distress in older adults. Larger randomized controlled trials are needed to confirm study findings.