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Chemical Species, Micromorphology, and XRD Fingerprint Analysis of Tibetan Medicine Zuotai Containing Mercury.
Bioinorganic Chemistry & Applications
Short Title: Bioinorganic Chemistry & Applications
Format: Journal Article
Publication Date: 2016/09/21/
Pages: 1 - 11
Sources ID: 93751
Notes: Accession Number: 118242581; Li, Cen 1,2 Yang, Hongxia 1,2 Du, Yuzhi 1,2 Xiao, Yuancan 1,2 Zhandui 3 Sanglao 4 Wang, Zhang 5 Ladan, Duojie 6 Bi, Hongtao 1,2 Wei, Lixin 1,2; Affiliation:  1: Pharmacology and Safety Evaluation Key Laboratory of Tibetan Medicine in Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China  2: Key Laboratory of Tibetan Medicine Research, Chinese Academy of Sciences, Xining, Qinghai 810008, China  3: Tibetan Traditional Medical College, Lhasa, Tibet 850000, China  4: Gansu Province Academy of Tibetan Medicine, Hezuo, Gansu 747000, China  5: Aba Prefecture Tibetan Medicine Hospital, Maerkang, Sichuan 624000, China  6: Qinghai Province Tibetan Medicine Hospital, Xining, Qinghai 810007, China; Source Info: 9/21/2016, p1; Subject Term: CHEMICAL species; Subject Term: TIBETAN medicine; Subject Term: MERCURY analysis; Subject Term: PHARMACODYNAMICS; Subject Term: X-ray diffraction; Subject Term: ENERGY dispersive X-ray spectroscopy; Number of Pages: 11p; Document Type: Article
Visibility: Public (group default)
Abstract: (Show)
Zuotai (gTso thal) is one of the famous drugs containing mercury in Tibetan medicine. However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray (EDX), scanning electron microscopy (SEM), atomic force microscopy (AFM), and powder X-ray diffraction (XRD) were used to assay the elements, micromorphology, and phase composition of nine Zuotai samples from different regions, respectively; the XRD fingerprint features of Zuotai were analyzed by multivariate statistical analysis. EDX result shows that Zuotai contains Hg, S, O, Fe, Al, Cu, and other elements. SEM and AFM observations suggest that Zuotai is a kind of ancient nanodrug. Its particles are mainly in the range of 100–800 nm, which commonly further aggregate into 1–30 μm loosely amorphous particles. XRD test shows that β-HgS, S8, and α-HgS are its main phase compositions. XRD fingerprint analysis indicates that the similarity degrees of nine samples are very high, and the results of multivariate statistical analysis are broadly consistent with sample sources. The present research has revealed the physicochemical characteristics of Zuotai, and it would play a positive role in interpreting this mysterious Tibetan drug. [ABSTRACT FROM AUTHOR]