A rapid, sensitive, and selective precolumn derivatization method for the simultaneous determination of eight thiophenols using 3-(2-bromoacetamido)-<i>N</i>-(9-ethyl-9<i>H</i>)-carbazol as a labeling reagent by high-performance liquid chromatography with fluorescence detection has been developed. The labeling reagent reacted with thiophenols at 50°C for 50 min in aqueous acetonitrile in the presence of borate buffer (0.10 mol/L, pH 11.2) to give high yields of thiophenol derivatives. The derivatives were identified by online postcolumn mass spectrometry. The collision-induced dissociation spectra for thiophenol derivatives gave the corresponding specific fragment ions at <i>m/z</i> 251.3, 223.3, 210.9, 195.8, and 181.9. At the same time, derivatives exhibited intense fluorescence with an excitation maximum at λ<sub>ex</sub> = 276 nm and an emission maximum at λ<sub>em</sub> = 385 nm. Excellent linear responses were observed for all analytes over the range of 0.033-6.66 μmol/L with correlation coefficients of more than 0.9997. Detection limits were in the range of 0.94-5.77 μg/L with relative standard deviations of less than 4.54%. The feasibility of derivatization allowed the development of a rapid and highly sensitive method for the quantitative analysis of trace levels of thiophenols from some rubber products. The average recoveries (<i>n</i> = 3) were in the range of 87.21-101.12%.
Meditation cultivates mindfulness, fosters a more peaceful mindset and help us realign.
Three new flavonol 3-O-glycosides, rhamnetin 3-O-[(S)-3-hydroxy-3-methyl-glutaroyl(1→6)]-β-D-glucopyranoside (1), rhamnocitrin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-β-D-glucopyranoside (2), and isorhamnetin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside (3), along with 13 known compounds, were isolated from Oxytropis racemosa TURCZ. Their structures were deduced by means of spectroscopic methods and chemical evidence. 2 and 6 showed cytotoxic activities against HCT-8 (IC₅₀ 6.38 µM) and A549 (IC₅₀ 5.20 µM), respectively.
Feel more settled and calm by spending a few minutes focused on your breathing. A 3-minute Mindful Breathing mindfulness meditation created by Stop, Breathe & Think.
In Tibetan Buddhist traditions, a distinction is made between the practice of medicine (sowa rigpa, i. e., the “science of healing”) and a broad range of nonmedical practices—including rituals, contemplative practices, and alchemy—that may be undertaken to promote health and long life, or to eliminate and impede conditions that cause disease.¹ The subject of this chapter is one such technique: a tantric meditation focusing on a popu lar trinity, the “three deities of longevity.” The meditation, which involves the visualization of consecration by the deities and the absorption of their life-sustaining forces, is introduced within the context of
Key mechanisms of action of psychosocial treatments for chronic pain include decreased catastrophizing and increased self-efficacy [cognitive-behavioral therapy (CBT)] and increased mindfulness and possibly pain acceptance [mindfulness-based stress reduction (MBSR)]. Greater understanding of overlap among these variables is important in understanding treatment-specific and shared mechanisms of action. We examined, in an RCT comparing group CBT (n=112), MBSR (n=116), and usual care (UC; n=113) for chronic back pain: (1) baseline relationships among the Pain Catastrophizing Scale (PCS), Pain Self-Efficacy Questionnaire (PSEQ), Chronic Pain Acceptance Questionnaire-8 (CPAQ-8), and Five Facet Mindfulness Questionnaire-short form (FFMQ-SF); and (2) pre- to post-treatment changes in these measures. We hypothesized that: (1) at baseline, the PCS would be associated negatively with the CPAQ-8, PSEQ, and FFMQ-SF Non-Reactivity, Non-Judging, and Acting with Awareness scales, and the CPAQ-8 would be associated positively with the PSEQ; and (2) adjusting for baseline variables, FFMQ-SF and CPAQ-8 scores would increase more pre- to post-treatment in MBSR than in CBT and UC, and PCS scores would decrease more and PSEQ scores would increase more in CBT than in MBSR and UC. The hypothesized baseline associations were confirmed between the PCS and the CPAQ-8 (Spearman’s rho = -0.40 to -0.55), PSEQ (-0.57), and FFMQ (-0.22 to -0.30) scales (all Ps < 0.01), and between the CPAQ-8 and the PSEQ (0.46-0.65; all Ps < 0.01). Among all participants who completed baseline and post-treatment assessments (n = 290), catastrophizing decreased significantly more pre- to post-treatment in MBSR than in UC and CBT. Among those who attended >6 of the 8 group sessions, mindfulness increased more in MBSR than in CBT, but the groups did not differ significantly in pre- to post-treatment change on the other measures. The results suggest overlap in mechanisms of action of CBT and MBSR. Supported by NCCAM grant 1R01AT006226.
Train to facilitate MBCT programs with guidance from Zindel Segal, one of its co-developers.Current treatments for depression provide relief for many people, yet they face significant challenges maintaining the benefits of treatment. This workshop and meditation retreat will lead you through an innovative 5-day intensive training program designed to prevent depressive relapse among people with a history of depression. Facilitators: Zindel Segal PhD C Psych, Patricia Rockman MD CCFP FCFP & Evan Collins MD FRCPC Location: Ecology Retreat Centre
Reduce stress, anxiety, and negative emotions, cool yourself down when your temper flares, and sharpen your concentration skills.
BackgroundStress and psychological distress are common in doctors and have adverse effects for both doctors and patients. Objective This study aimed to investigate the long-term (5-year) effects of mindfulness practice on medical practitioners’ stress. Methods A 5-year follow-up study using quantitative and qualitative data analysis. Outcome measures of the original trial, Perceived Stress Scale (PSS) and Depression, Anxiety, Stress Scale (DASS), were repeated and a questionnaire/interview on doctors’ health and well-being was undertaken. Results Most participants (88%) continue to use mindfulness or relaxation exercises. Mean outcome scores (and standard deviations) at 5 year follow up revealed; PSS 13.8 (5.2) (maximal score of 40), anxiety subscale of DASS 4.4 (4.9) (maximal score of 42 and stress subscale of DASS 10.9 (7.3) (maximal score of 42). The 5 year follow up group mean PSS and DASS outcomes scores were all lower than post intervention scores from the original RCT, however differences were not statistically significant. Participants expressed concerns with the overall state of doctors’ health/wellbeing. Conclusion Mindfulness for stress management is sustainable and may be beneficial for long term use in doctors.
Precious Pills, also called Jewel Pills because of their precious stone and jewel content, are among the most popu lar and well-known Tibetan medicines today. We know very little about their origins and the development of their recipes, however, as most of the related lit er a ture is only available in Tibetan .. and has not yet been translated or deeply studied by scholars working in European languages. Precious Pills are compounds that contain between twenty-five and 160 plants and minerals, as well as precious ingredients such as gold, silver, rubies, diamonds, corals, turquoise, pearls, sapphires, anddzibeads
The last of the 156 chapters of theFour Treatises, which is presented here, is a fitting conclusion to this poetic root text of Tibetan medicine said to date back to the twelfth century. It is not called “Conclusion” (as the chapter before it), however. Instead, it is titled “Entrustment,”¹ and it begins with a fundamental question of doubt. The following question prob ably arises in the mind of any medical practitioner at some point:What is the purpose of possessing the knowledge of healing and being a physician if treatments can fail and people still die? This core question of
There were numerous traditions of healing in Tibet. Many centered on ritual puri-fication or the ingestion of sacralized substances. Many invoked Buddhist deities, and some were connected to Indian Buddhist texts on healing. But the mainstream practice of the “science of healing”(sowa rigpa)in Tibet depended instead on physical means of healing. These were adapted from Indian Ayurveda, East Asian diagnostics, Central Asian medicine, and knowledge from Greco-Arabic medicine. They involved medicinal herbs, balance of the bodily humors, moxibustion, bloodletting, massage, splints, purgatives, and surgery. These are described in the classic text of Tibetan medicine,the Four Treatises (Gyushi;see
Dana Falsetti is a yoga instructor with a simple but revolutionary idea--yoga should be for everybody. Campaigning for equality, shame disruption, empowerment, sexual freedom and confidence, Dana has gained an online following of more than half a million people. She has traveled worldwide, hosting dozens of workshops for those seeking similar insights, and several of her viral videos have gleaned more than 20 million views. Dana won the 2017 Shorty Award for Health and Wellness on Social Media and had been featured in publications such as Seventeen, Women’s Health, People, Cosmopolitan, Huffington Post and Buzzfeed, among others. She has built her own platform where yoga students pay only what they can afford, for a practice that suits their ability status, and where compassion is at the heart of every lesson.Dana’s message really does just boil down to compassion for people of all sizes, all races, all ages, and all ability statuses. The lack of empathy in diet culture and the corporate wellness industry has led to a very visual and commercial understanding of “health.” Dana advocates for a broader, more holistic understanding of health that cannot be determined by your BMI (body mass index). Like many people, Dana dealt with a lot of shame throughout her life. She believed that she had to be a specific weight and reach a certain standard of beauty, to be allowed to thrive in modern society. Five years ago, she found yoga, and it helped pull her out of the insidious grasp of diet culture. While Dana has had her ups and downs during her yoga journey, she has reached a point where existing as herself and living her best life in the body is her highest truth - and she's helping others do the same.
A mindfulness practice from Shamash Alidina's "The Mindful Way Through Stress: http://www.shamashalidina.com/books/
You have about 80,000 hours in your career: 40 hours a week, 50 weeks a year, for 40 years. This means your choice of career is one of the most important decisions you’ll ever make. Make the right choices, and you can help solve some of the world’s most pressing problems, as well as have a more rewarding, interesting life. For such an important decision, however, there’s surprisingly little good advice out there.Most career advice focuses on things like how to write a CV, and much of the rest is just (misleading) platitudes like “follow your passion”. Most people we speak to don’t even use career advice – they just speak to friends and try to figure it out for themselves. When it comes to helping others with your career, the advice usually assumes you need to work as a teacher, doctor, charity worker, and so on, even though these paths might not be a good fit for you, and were not what the highest-impact people in history did. This guide is based on five years of research conducted alongside academics at the University of Oxford. It aims to help you find a career you enjoy, you’re good at, and that tackles the world’s most pressing problems. It covers topics like: 1. What makes for a dream job, and why “follow your passion” can be misleading. 2. Why the most effective ways to make a difference aren’t always the obvious ones like working at a charity, or becoming a doctor. 3. How to compare global problems, like climate change and education, in terms of their scale and urgency. 4. How to discover and develop your strengths. It’s also full of practical tips and tools. At the end, you'll have a plan to use your career in a way that's fulfilling and does good.
Phytochemical studies on the whole herb of Sphaerophysa salsula has resulted in the discovery of one new 8-isopentenyl isoflavone derivative, named sphaerosin s2 (3-(8-(2-hydroxypropan-2-yl)-3,4-dihydro-2H-furo[2,3-h]chromen-3-yl)-2,6-dimethoxyphenol) (1), along with four know 8-isopentenyl isoflavone derivatives (2-5). Compounds (2, 4 and 5) were isolated for the first time from this species. Their structures were elucidated on the basis of ESI-MS, UV, IR, 1D NMR and 2D NMR data.
This panel proposes to bring together scholars and practitioners for a multidisciplinary exploration of ‘potent substances’—the herbal, fungal, mineral, metal, and animal-based materia medica at the heart of Asian medicines. We aim to discuss issues
<p>Mindfulness-based therapy (MBT) has shown promise in reducing depression and psychological distress among individuals presenting with various medical and psychiatric problems. This case study examined the implementation of MBT with an undergraduate student with recurrent major depression and generalized anxiety disorder. A novel four-session MBT protocol was utilized and the patient demonstrated significant decreases in depressive and anxiety symptoms and an overall increase in quality of life at the posttreatment assessment. Treatment gains were maintained at the 1-month follow-up assessment. Consistent with previous treatment outcome studies examining the efficacy of comprehensive MBT interventions, results indicate that an abbreviated MBT protocol may be effective in treating depression and anxiety in younger adults.</p>
"The ABCs of Yoga for Kids around the World is a fun-filled tour of 29 countries, introducing kid-friendly, easy-to-learn yoga poses along the way. A follow-up to the bestselling The ABCs of Yoga for Kids and written in honor of International Kids Yoga Day, this book features beautiful illustrations, charming rhymes, and fun facts about this wonderful world in which we live."--