The experience of aversion is shaped by multiple physiological and psychological factors including one's expectations. Recent work has shown that expectancy manipulation can alter perceptions of aversive events and concomitant brain activation. Accruing evidence indicates a primary role of altered expectancies in the placebo effect. Here, we probed the mechanism by which expectation attenuates sensory taste transmission by examining how brain areas activated by misleading information during an expectancy period modulate insula and amygdala activation to a highly aversive bitter taste. In a rapid event-related fMRI design, we showed that activations in the rostral anterior cingulate cortex (rACC), orbitofrontal cortex (OFC), and dorsolateral prefrontal cortex to a misleading cue that the taste would be mildly aversive predicted decreases in insula and amygdala activation to the highly aversive taste. OFC and rACC activation to the misleading cue were also associated with less aversive ratings of that taste. Additional analyses revealed consistent results demonstrating functional connectivity among the OFC, rACC, and insula. Altering expectancies of upcoming aversive events are shown here to depend on robust functional associations among brain regions implicated in prior work on the placebo effect.
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Background
A key to successful adaptation is the ability to regulate emotional responses in relation to changing environmental demands or contexts.
Methods
High-resolution PET 18fluoro-deoxyglucose (FDG) scanning in rhesus monkeys was performed during two contexts (alone, and human intruder with no eye contact) during which the duration of anxiety related freezing behavior was assessed. Correlations between individual differences in freezing duration and brain activity were performed for each of the two conditions, as well as for the contextual regulation between the two conditions.
Results
In both conditions, activity in the basal forebrain, including the bed nucleus of the stria terminalis and the nucleus accumbens were correlated with individual differences in freezing duration. In contrast, individual differences in the ability to regulate freezing behavior between contexts were correlated with activity in the dorsal anterior cingulate cortex, the thalamus and the dorsal raphe nucleus.
Conclusions
These findings demonstrate differences in the neural circuitry mediating the expression compared to the contextual regulation of freezing behavior. These findings are relevant since altered regulatory processes may underlie anxiety disorders.
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Neuroscientists should help to develop compelling video games that boost brain function and improve well-being, say Daphne Bavelier and Richard J. Davidson.
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Purpose
Evaluate impact of breathing awareness meditation (BAM), Botvin LifeSkills® Training (LST), and health education control (HEC) on ambulatory blood pressure (BP) and sodium excretion in African American (AA) adolescents.
Methods
Following three consecutive days of systolic blood pressure (SBP) screenings, 166 eligible participants (i.e., SBP > 50th – 95th percentile) were randomized by school to either BAM (n = 53), LST (n= 69), or HEC (n=44). In-school intervention sessions were administered for three months by health education teachers. Before and after the intervention overnight urine samples and 24-hour ambulatory SBP, diastolic blood pressure (DBP), and heart rate (HR) were obtained.
Results
Significant group differences were found for changes in overnight SBP and SBP, DBP and HR over the 24-hour period and during school hours. The BAM treatment exhibited the greatest overall decreases on these measures (Bonferroni adjusted, ps <.05). For example, for school-time SBP, BAM showed a change of −3.7 mmHg compared to no change for LST and a change of −0.1 mmHg for HEC. There was a non-significant trend for overnight urinary sodium excretion (p = .07) with the BAM group displaying a reduction of −.92 ± 1.1 mEq/hr compared to increases of .89 ± 1.2 mEq/hr for LST, and .58±0.9 mEq/hr for HEC group.
Conclusion
BAM appears to improve hemodynamic function and may impact sodium handling among AA adolescents at increased risk for development of cardiovascular disease (CVD).
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Given the limited success of conventional treatments for veterans with posttraumatic stress disorder (PTSD), investigations of alternative approaches are warranted. We examined the effects of a breathing-based meditation intervention, Sudarshan Kriya yoga, on PTSD outcome variables in U.S. male veterans of the Iraq or Afghanistan war. We randomly assigned 21 veterans to an active (n = 11) or waitlist control (n = 10) group. Laboratory measures of eye-blink startle and respiration rate were obtained before and after the intervention, as were self-report symptom measures; the latter were also obtained 1 month and 1 year later. The active group showed reductions in PTSD scores, d = 1.16, 95% CI [0.20, 2.04], anxiety symptoms, and respiration rate, but the control group did not. Reductions in startle correlated with reductions in hyperarousal symptoms immediately postintervention (r = .93, p < .001) and at 1-year follow-up (r = .77, p = .025). This longitudinal intervention study suggests there may be clinical utility for Sudarshan Kriya yoga for PTSD.
Given the limited success of conventional treatments for veterans with posttraumatic stress disorder (PTSD), investigations of alternative approaches are warranted. We examined the effects of a breathing-based meditation intervention, Sudarshan Kriya yoga, on PTSD outcome variables in U.S. male veterans of the Iraq or Afghanistan war. We randomly assigned 21 veterans to an active (n = 11) or waitlist control (n = 10) group. Laboratory measures of eye-blink startle and respiration rate were obtained before and after the intervention, as were self-report symptom measures; the latter were also obtained 1 month and 1 year later. The active group showed reductions in PTSD scores, d = 1.16, 95% CI [0.20, 2.04], anxiety symptoms, and respiration rate, but the control group did not. Reductions in startle correlated with reductions in hyperarousal symptoms immediately postintervention (r = .93, p < .001) and at 1-year follow-up (r = .77, p = .025). This longitudinal intervention study suggests there may be clinical utility for Sudarshan Kriya yoga for PTSD.
Given the limited success of conventional treatments for veterans with posttraumatic stress disorder (PTSD), investigations of alternative approaches are warranted. We examined the effects of a breathing-based meditation intervention, Sudarshan Kriya yoga, on PTSD outcome variables in U.S. male veterans of the Iraq or Afghanistan war. We randomly assigned 21 veterans to an active (n = 11) or waitlist control (n = 10) group. Laboratory measures of eye-blink startle and respiration rate were obtained before and after the intervention, as were self-report symptom measures; the latter were also obtained 1 month and 1 year later. The active group showed reductions in PTSD scores, d = 1.16, 95% CI [0.20, 2.04], anxiety symptoms, and respiration rate, but the control group did not. Reductions in startle correlated with reductions in hyperarousal symptoms immediately postintervention (r = .93, p < .001) and at 1-year follow-up (r = .77, p = .025). This longitudinal intervention study suggests there may be clinical utility for Sudarshan Kriya yoga for PTSD.
Objective: To evaluate feasibility, efficacy, and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment.Methods: Patients with MDD (defined by DSMIV-TR) who were depressed despite ≥ 8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8 weeks. The primary efficacy end point was change in 17-item Hamilton Depression Rating Scale (HDRS-17) total score from baseline to 2 months. The key secondary efficacy end points were change in Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) total scores. Analyses of the intent-to-treat (ITT) and completer sample were performed. The study was conducted at the University of Pennsylvania between October 2014 and December 2015.
Results: In the ITT sample (n = 25), the SKY arm (n = 13) showed a greater improvement in HDRS17 total score compared to waitlist control (n = 12) (−9.77 vs 0.50, P = .0032). SKY also showed greater reduction in BDI total score versus waitlist control (−17.23 vs −1.75, P = .0101). Mean changes in BAI total score from baseline were significantly greater for SKY than waitlist (ITT mean difference: −5.19; 95% CI, −0.93 to −9.34; P = .0097; completer mean difference: −6.23; 95% CI, −1.39 to −11.07; P = .0005). No adverse events were reported.
Conclusions: Results of this randomized, waitlistcontrolled pilot study suggest the feasibility and promise of an adjunctive SKY-based intervention for patients with MDD who have not responded to antidepressants. Trial Registration: ClinicalTrials.gov identifier: NCT02616549 J Clin Psychiatry 2017;78(1):e59–e63 dx.doi.org/10.4088/JCP.16m10819 © Copyright 2016 Physicians Postgraduate Press, Inc.
Contemplative practices, such as meditation and yoga, are increasingly popular among the general public and as topics of research. Beneficial effects associated with these practices have been found on physical health, mental health and cognitive performance. However, studies and theories that clarify the underlying mechanisms are lacking or scarce. This theoretical review aims to address and compensate this scarcity. We will show that various contemplative activities have in common that breathing is regulated or attentively guided. This respiratory discipline in turn could parsimoniously explain the physical and mental benefits of contemplative activities through changes in autonomic balance. We propose a neurophysiological model that explains how these specific respiration styles could operate, by phasically and tonically stimulating the vagal nerve: respiratory vagal nerve stimulation (rVNS). The vagal nerve, as a proponent of the parasympathetic nervous system (PNS), is the prime candidate in explaining the effects of contemplative practices on health, mental health and cognition. We will discuss implications and limitations of our model.
Contemplative practices, such as meditation and yoga, are increasingly popular among the general public and as topics of research. Beneficial effects associated with these practices have been found on physical health, mental health, and cognitive performance. However, studies and theories that clarify the underlying mechanisms are lacking or scarce. This theoretical review aims to address and compensate this scarcity. We will show that various contemplative activities have in common that breathing is regulated or attentively guided. This respiratory discipline in turn could parsimoniously explain the physical and mental benefits of contemplative activities through changes in autonomic balance. We propose a neurophysiological model that explains how these specific respiration styles could operate, by phasically and tonically stimulating the vagal nerve: respiratory vagal nerve stimulation. The vagal nerve, as a proponent of the parasympathetic nervous system, is the prime candidate in explaining the effects of contemplative practices on health, mental health, and cognition. We will discuss implications and limitations of our model.
Biological systems are particularly prone to variation, and the authors argue that such variation must be regarded as important data in its own right. The authors describe a method in which individual differences are studied within the framework of a general theory of the population as a whole and illustrate how this method can be used to address three types of issues: the nature of the mechanisms that give rise to a specific ability, such as mental imagery; the role of psychological or biological mediators of environmental challenges, such as the biological bases for differences in dispositional mood; and the existence of processes that have nonadditive effects with behavioral and physiological variables, such as factors that modulate the response to stress and its effects on the immune response.
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The relationship between positive emotions and implicit racial prejudice is unclear. Interventions using positive emotions to reduce racial bias have been found wanting, while other research shows that positive affect can sometimes exacerbate implicit prejudice. Nevertheless, loving-kindness meditation (LKM) has shown some promise as a method of reducing bias despite increasing a broad range of positive emotions. A randomised control trial (n = 69) showed that a short-term induction of LKM decreased automatic processing, increased controlled processing, and was sufficient to reduce implicit prejudice towards the target’s racial group but not towards a group untargeted by the meditation. Furthermore, the reduction in bias was shown to be mediated by other-regarding positive emotions alongside increased control and decreased automaticity on the IAT. Non-other-regarding positive emotions conversely showed no correlation with bias. The study is the first to show that a short-term positive emotional induction can reduce racial prejudice, and aids the understanding of how positive emotions functionally differentiate in affecting bias.
The relationship between positive emotions and implicit racial prejudice is unclear. Interventions using positive emotions to reduce racial bias have been found wanting, while other research shows that positive affect can sometimes exacerbate implicit prejudice. Nevertheless, loving-kindness meditation (LKM) has shown some promise as a method of reducing bias despite increasing a broad range of positive emotions. A randomised control trial (n = 69) showed that a short-term induction of LKM decreased automatic processing, increased controlled processing, and was sufficient to reduce implicit prejudice towards the target’s racial group but not towards a group untargeted by the meditation. Furthermore, the reduction in bias was shown to be mediated by other-regarding positive emotions alongside increased control and decreased automaticity on the IAT. Non-other-regarding positive emotions conversely showed no correlation with bias. The study is the first to show that a short-term positive emotional induction can reduce racial prejudice, and aids the understanding of how positive emotions functionally differentiate in affecting bias.
Mindfulness meditation is increasingly used in health interventions and may reduce stress and blood pressure. We aimed to investigate the effectiveness of brief mindfulness meditation in reducing cardiovascular reactivity and recovery during a laboratory stressor. We randomly assigned 62 meditation-naïve participants to a mindfulness meditation group or a matched non-mindful listening exercise control group. There were no differences between groups in blood pressure, demographic, or mood variables at baseline. Mindfulness participants showed lower systolic blood pressure following the mindfulness exercise and decreased systolic and diastolic blood pressure reactivity during a speeded math stressor. Specifically, as the stressor progressed, blood pressure in the mindfulness group began to decrease, whereas in the control group, it continued to increase. There were no group differences during recovery. Overall, brief mindfulness meditation reduced cardiovascular reactivity to stress and may be an effective intervention for reducing stress-related blood pressure reactivity.
Mindfulness meditation is increasingly used in health interventions and may reduce stress and blood pressure. We aimed to investigate the effectiveness of brief mindfulness meditation in reducing cardiovascular reactivity and recovery during a laboratory stressor. We randomly assigned 62 meditation-naïve participants to a mindfulness meditation group or a matched non-mindful listening exercise control group. There were no differences between groups in blood pressure, demographic, or mood variables at baseline. Mindfulness participants showed lower systolic blood pressure following the mindfulness exercise and decreased systolic and diastolic blood pressure reactivity during a speeded math stressor. Specifically, as the stressor progressed, blood pressure in the mindfulness group began to decrease, whereas in the control group, it continued to increase. There were no group differences during recovery. Overall, brief mindfulness meditation reduced cardiovascular reactivity to stress and may be an effective intervention for reducing stress-related blood pressure reactivity.
Background and objectives Up to 50% of patients undergoing hemodialysis suffer from symptoms of depression and/or anxiety. Access to traditional pharmacotherapies and psychotherapies for depression or anxiety in this patient population has been inadequate. The objective of this study was to investigate the feasibility and effectiveness of brief mindfulness meditation intervention for patients on hemodialysis with depression and anxiety symptoms.Design, setting, participants, & measurements This study was a randomized, controlled, assessor-blinded trial conducted in an urban hemodialysis unit. Forty-one patients were randomly assigned to intervention (n=21) and treatment-as-usual (n=20) groups. The intervention group received an 8-week individual chairside meditation intervention lasting 10–15 minutes, three times a week during hemodialysis. Feasibility outcomes were primarily assessed: enrollment rates, intervention completion rates, and intervention tolerability. Symptoms of depression and anxiety were measured using the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder-7 (GAD-7).
Results Of those deemed eligible for the study, 67% enrolled (41 of 61). Of the participants randomized to the intervention group, 71% completed the study, with meditation being well tolerated (median rating of 8 of 10 in a Likert scale; interquartile range=10–5 of 10). Barriers to intervention delivery included frequent hemodialysis shift changes, interruptions by staff or alarms, space constraints, fluctuating participant medical status, and participant fatigue. Meditation was associated with subjective benefits but no statistically significant effect on depression scores (change in PHQ-9, −3.0±3.9 in the intervention group versus −2.0±4.7 in controls; P=0.45) or anxiety scores (change in GAD-7, −0.9±4.6 versus −0.8±4.8; P=0.91).
Conclusions On the basis of the results of this study, mindfulness meditation appears to be feasible and well tolerated in patients on hemodialysis with anxiety and depression symptoms. The study did not reveal significant effects of the interventions on depression and anxiety scores.
OBJECTIVE:To test whether a brief mindfulness meditation training intervention buffers self-reported psychological and neuroendocrine responses to the Trier Social Stress Test (TSST) in young adult volunteers. A second objective evaluates whether pre-existing levels of dispositional mindfulness moderate the effects of brief mindfulness meditation training on stress reactivity.
METHODS:
Sixty-six (N=66) participants were randomly assigned to either a brief 3-day (25-min per day) mindfulness meditation training or an analytic cognitive training control program. All participants completed a standardized laboratory social-evaluative stress challenge task (the TSST) following the third mindfulness meditation or cognitive training session. Measures of psychological (stress perceptions) and biological (salivary cortisol, blood pressure) stress reactivity were collected during the social evaluative stress-challenge session.
RESULTS:
Brief mindfulness meditation training reduced self-reported psychological stress reactivity but increased salivary cortisol reactivity to the TSST, relative to the cognitive training comparison program. Participants who were low in pre-existing levels of dispositional mindfulness and then received mindfulness meditation training had the greatest cortisol reactivity to the TSST. No significant main or interactive effects were observed for systolic or diastolic blood pressure reactivity to the TSST.
CONCLUSIONS:
The present study provides an initial indication that brief mindfulness meditation training buffers self-reported psychological stress reactivity, but also increases cortisol reactivity to social evaluative stress. This pattern may indicate that initially brief mindfulness meditation training fosters greater active coping efforts, resulting in reduced psychological stress appraisals and greater cortisol reactivity during social evaluative stressors.
ObjectiveTo test whether a brief mindfulness meditation training intervention buffers self-reported psychological and neuroendocrine responses to the Trier Social Stress Test (TSST) in young adult volunteers. A second objective evaluates whether pre-existing levels of dispositional mindfulness moderate the effects of brief mindfulness meditation training on stress reactivity.
Methods
Sixty-six (N = 66) participants were randomly assigned to either a brief 3-day (25-min per day) mindfulness meditation training or an analytic cognitive training control program. All participants completed a standardized laboratory social-evaluative stress challenge task (the TSST) following the third mindfulness meditation or cognitive training session. Measures of psychological (stress perceptions) and biological (salivary cortisol, blood pressure) stress reactivity were collected during the social evaluative stress-challenge session.
Results
Brief mindfulness meditation training reduced self-reported psychological stress reactivity but increased salivary cortisol reactivity to the TSST, relative to the cognitive training comparison program. Participants who were low in pre-existing levels of dispositional mindfulness and then received mindfulness meditation training had the greatest cortisol reactivity to the TSST. No significant main or interactive effects were observed for systolic or diastolic blood pressure reactivity to the TSST.
Conclusions
The present study provides an initial indication that brief mindfulness meditation training buffers self-reported psychological stress reactivity, but also increases cortisol reactivity to social evaluative stress. This pattern may indicate that initially brief mindfulness meditation training fosters greater active coping efforts, resulting in reduced psychological stress appraisals and greater cortisol reactivity during social evaluative stressors.
<p>The article brings out information on groups of untouchables, the Chirmar people of Belsapur village in Banke, Nepal. Actually this article is written in the style of "notes preliminaries" pioneered by French social scientists in Nepal. It is a by-product of a larger research undertaking under the auspices of and with a grant from the Institute of Nepal and Asian Studies, Tribhuwan University. In 1857 the four districts of Banke, Bardia, Kailai and Kanchanpur, collectively called Nayamuluk, were returned to Nepal by the British in recognition of the military aid provided by Jung Bahadur Rana to quell the Indian rebellion. The Chirmar groups are inhabitants of Banke where only four Chirmar households in Belsapur have land of their own. It discusses their cultural practices such as wedding ceremonies. It focuses on their poor status economically. It includes 4 leaves of plates. (Rajeev Ranjan Singh 2007-01-12)</p>
<p>The author argues that for understanding of Jirel cultural meanings, in-depth investigation of all aspects of their language is necessary. The article then surveys some Jirel vocabulary. Jirel is one of the languages included in the Sino-Tibetan language family. The article includes tables containing Jirel kin terms and their extensions, raksi and chang vocabulary, and Jirel household terms. (Rajeev Ranjan Singh 2006-10-12)</p>
OBJECTIVES: Fatigue and other treatment-related symptoms (e.g., sleep disturbance) are critical targets for improving quality of life in patients undergoing chemotherapy. Yoga may reduce the burden of such symptoms. This study investigated the feasibility of conducting a randomized controlled study of a brief yoga intervention during chemotherapy for colorectal cancer.DESIGN: We randomized adults with colorectal cancer to a brief Yoga Skills Training (YST) or an attention control (AC; empathic attention and recorded education).
SETTING: The interventions and assessments were implemented individually in the clinic while patients were in the chair receiving chemotherapy.
INTERVENTIONS: Both interventions consisted of three sessions and recommended home practice.
MAIN OUTCOME MEASURES: The primary outcome was feasibility (accrual, retention, adherence, data collection). Self-reported outcomes (i.e., fatigue, sleep disturbance, quality of life) and inflammatory biomarkers were also described to inform future studies.
RESULTS: Of 52 patients initially identified, 28 were approached, and 15 enrolled (age Mean = 57.5 years; 80% White; 60% Male). Reasons for declining participation were: not interested (n = 6), did not perceive a need (n = 2), and other (n = 5). Two participants were lost to follow-up in each group due to treatment changes. Thus, 75% of participants were retained in the YST and 71% in the AC arm. Participants retained in the study adhered to 97% of the in-person intervention sessions and completed all questionnaires.
CONCLUSIONS: This study demonstrated the feasibility of conducting a larger randomized controlled trial to assess YST among patients receiving chemotherapy for colorectal cancer. Data collected and challenges encountered will inform future research.
Social and emotional learning (SEL) has as its goals to strengthen a person's ability to understand, manage, and express the social and emotional aspects of life. The authors, all of whom have worked in training teachers in the promotion of students' social and emotional skills, have found that educators often view efforts at building such skills as standing in opposition to the academic focus of their state curriculum standards. This view hinders many well-intentioned teachers from implementing SEL in their classrooms. Thus, it is a valuable consultative tool to be able to demonstrate the overlap of SEL, academics, and curriculum standards. The authors set out a rationale for this overlap and provide examples of how they incorporate this overlap into their training and consultation.
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