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Mindfulness has been garnering increased attention within the area of clinical psychology due to its theorized and empirical associations with psychological well-being. Using a sample of patients diagnosed with digestive tract cancer ( N = 292), we examined the relationship between perceived stress and psychological symptoms at varying levels of dispositional mindfulness. Results showed significant associations between perceived stress and psychological symptoms. More importantly, the relationship between perceived stress and psychological symptoms was only significant for patients with low, but not high, levels of dispositional mindfulness. Implications and future research directions were discussed.