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Objective: To provide a descriptive overview of the clinical trials assessing meditation practices for health care.Design: Systematic review of the literature. Comprehensive searches were conducted in 17 electronic bibliographic databases through September 2005. Other sources of potentially relevant studies included hand searches, reference tracking, contacting experts, and gray literature searches. Included studies were clinical trials with 10 or more adult participants using any meditation practice, providing quantitative data on health-related outcomes, and published in English. Two independent reviewers assessed study relevance, extracted the data, and assessed the methodological quality of the studies.Results: Four hundred clinical trials on meditation (72% described as randomized) were included in the review (publication years 1956–2005). Five broad categories of meditation practices were identified: mantra meditation, mindfulness meditation, yoga, t'ai chi, and qigong. The three most studied clinical conditions were hypertension, miscellaneous cardiovascular diseases, and substance abuse. Psychosocial measures were the most frequently reported outcomes. Outcome measures of psychiatric and psychological symptoms dominate the outcomes of interest. Overall, the methodological quality of clinical trials is poor, but has significantly improved over time by 0.014 points every year (95% CI, 0.005, 0.023).Conclusions: Most clinical trials on meditation practices are generally characterized by poor methodological quality with significant threats to validity in every major quality domain assessed. Despite a statistically significant improvement in the methodological quality over time, it is imperative that future trials on meditation be rigorous in design, execution, analysis, and the reporting of results.

This study examined the relationship between mindfulness and emotion regulation in nursing students as well as the potential mediator role of working memory capacity in this relationship. The Mindful Attention Awareness Scale (MAAS), Emotion Regulation Questionnaire (ERQ), and an Automated Operation Span Task (AOSPAN) were administered to 80 undergraduate pre-licensure baccalaureate nursing students. Pearson correlation, structural equation path modeling, and one-way ANOVA tests were conducted. MAAS scores were significantly correlated with ERQ-Reappraisal scores (r = 0.19, p = 0.045) and AOSPAN scores (r = 0.30, p = 0.004). A structural equation path model indicated that there was a direct effect of dispositional mindfulness on emotion regulation (γ11 = 0.29, p = 0.034) and working memory capacity (γ21 = 4.98, p = 0.004). However, working memory capacity did not directly mediate the effect of mindfulness on emotion regulation (b weight = −0.03, p = 0.236). Also, MAAS scores were significantly different (p < 0.05) between the student cohort levels, with the first semester students having the highest MAAS scores and the fourth semester students have the lowest MAAS scores. These findings suggest that mindfulness may influence prospective nursing professionals’ working memory capacity and ability to regulate emotions. However, working memory capacity did not explain how mindfulness influenced the use of reappraisal as an emotion regulation strategy. Nurse educators should consider other potential mechanisms of how mindfulness influences emotion regulation in nursing students. Furthermore, educators should consider that potential differences in mindfulness exist between nursing students when they implement mindfulness-based interventions.

Understanding the autonomic nervous system and homeostatic changes associated with emotions remains a major challenge for neuroscientists and a fundamental prerequisite to treat anxiety, stress, and emotional disorders. Based on recent publications, the inter-relationship between respiration and emotions and the influence of respiration on autonomic changes, and subsequent widespread membrane potential changes resulting from changes in homeostasis are discussed. We hypothesize that reversing homeostatic alterations with meditation and breathing techniques rather than targeting neurotransmitters with medication may be a superior method to address the whole body changes that occur in stress, anxiety, and depression. Detrimental effects of stress, negative emotions, and sympathetic dominance of the autonomic nervous system have been shown to be counteracted by different forms of meditation, relaxation, and breathing techniques. We propose that these breathing techniques could be used as first-line and supplemental treatments for stress, anxiety, depression, and some emotional disorders.