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The conceit that either mind is reducible to matter or that mind is utterly ethereal is rooted in a mind-versus-matter dichotomy that can be characterized as the modern error, a fatally flawed fallacy rooted in the philosophy and culture of nominalism. A Peircean semiotic outlook, applied to an understanding of social life, provides a new and full-bodied understanding of semiosis as the bridge between mind and matter, and human biology and culture. I begin by first delineating the false divide and showing Charles Sanders Peirce's alternative to it, then explore the implications of a semiotic approach to mind as transaction, then consider the self-transcending nature of the human body-mind. Finally I outline my ecological, biosemiotic account of mind, which reveals that, indeed, mind matters, and in ways that unexpectedly resemble the forms of animism that characterized the hunting-gathering foragers through whom we anatomically modern humans emerged.