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Mindfulness training involves the cultivation of nonjudgemental attention to unwanted thoughts, feelings and bodily experiences via meditation and may help ameliorate both psychological and physical symptoms of chronic disease. Clinical trials have shown that mindfulness training improves the psychological well-being of people with rheumatoid arthritis(RA). However, there is limited evidence for its efficacy on disease activity outcomes in RA. Given evidence linking increased mindfulness to improved immune markers, mindfulness training may reduce disease activity in patients with RA by enhancing their immune function. The aim of this randomised controlled trial was to examine the effects of a standardised mindfulness-based stress reduction (MBSR) intervention on RA disease activity.