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The dynamics of sexual and social selection are overviewed for humans, and the associated traits are used to identify sex-specific vulnerabilities. These include vulnerabilities in physical growth and development, social relationships, and in brain and cognition. Sex-specific traits are identified in each of these areas, and identified as being especially vulnerable during childhood, adolescence, or adulthood. The identified traits, in turn, are used to organize reviews of human vulnerabilities described in subsequent chapters.