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Favorite Table | PrintPruritus at a GlancePruritus is the predominant symptom of skin disease. May originate in the skin or nervous system.Clinical classification of itch includes:pruritus on diseased (inflamed) skinpruritus on nondiseased (noninflamed) skinpruritus presenting with severe chronic secondary scratch lesionsChronic itch consists of multidimensional phenomena including sensory, emotional, and cognitive components.Central and peripheral mediators in humans include histamine, proteinases, opiates, substance P, nerve growth factor, interleukins, and prostaglandins.Treatment should address the multifactorial nature of pruritus including central pathways and peripheral mediators.