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The extraction and solvent partition of roots of <i>Incarvillea compacta</i>, a traditional Tibetan folk medicine, and repeated column chromatography and preparative high-performance liquid chromatography for <i>n</i>-butanol fraction yielded four phenylethanoid glycosides, crenatoside (<i>1</i>), 3′′′-<i>O</i>-methylcrenatoside (<i>2</i>), leucoseceptoside A (<i>3</i>), and martynoside (<i>4</i>). The chemical structures were identified on the basis of spectroscopic data analyses including NMR and MS. All compounds were isolated for the first time from the plant. Compound <i>1</i> exerted better 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity. In addition, compounds <i>1</i>-<i>4</i> were evaluated for their hepatoprotective activity on carbon tetrachloride (CCl<sub>4</sub>)-induced liver injury in HepG2 cells. Pretreatment of HepG2 cells with compound <i>1</i>-<i>4</i> significantly increased the viability on CCl<sub>4</sub>-induced cell death. Furthermore, compounds <i>1</i>-<i>4</i> also alleviated CCl<sub>4</sub>-induced hepatotoxicity by enhancement of the antioxidant enzyme activities of superoxide dismutase and reduction of the malondialdehyde content, intracellular ROS as well as NF-κB transactivation. Our results suggest that phenylethanoid glycosides ameliorate CCl<sub>4</sub>-induced cell injury, and this protection was likely due to antioxidative activity and down-regulation of NF-κB.