Displaying 1 - 3 of 3
Biocompatible and bioresponsive microneedles (MNs) are emerging technology platforms for sustained drug release with a potential to be a key player in transdermal delivery of therapeutics. In this paper, an innovative biodegradable MNs patch for the sustained delivery of drugs using a polymer patch, which can adjust delivery rates based on its crosslinking degree, is reported. Gelatin methacryloyl (GelMA) is used as the base for engineering biodegradable MNs. The anticancer drug doxorubicin (DOX) is loaded into GelMA MNs using the one molding step. The GelMA MNs can efficiently penetrate the <i>stratum corneum</i> layer of a mouse cadaver skin. Mechanical properties and drug release behavior of the GelMA MNs can be adjusted by tuning the degree of crosslinking. The efficacy of the DOX released from the GelMA MNs is tested and the anticancer efficacy of the released drugs against melanoma cell line A375 is demonstrated. Since GelMA is a versatile material in engineering tissue scaffolds, it is expected that the GelMA MNs can be used as a platform for the delivery of various therapeutics.<br><b>A biocompatible and biodegradable microneedles patch</b> based on gelatin methacryloyl are developed for transcutaneous delivery of drugs. The microneedles can efficiently penetrate the <i>stratum corneum</i> layer in a mouse cadaver skin model and the drug release profile can be controlled by tuning the crosslinking degrees. The model drug doxorubicin keeps its anticancer efficacy after enzyme-mediated release from the patch.
The present study examined the reliability and validity of a Chinese translation of the Mindful Attention Awareness Scale (MAAS). Three questionnaires, the MAAS, the Positive and Negative Affect Schedule (PANAS), and the brief version of the World Health Organization's Quality of Life (WHOQOL-BREF), were completed by 263 Chinese undergraduates (207 males, 56 females). Seventy of these students were assessed again with the MAAS after 20 days to evaluate the scale's test–retest reliability. Results from confirmatory factory analysis indicated that a one-factor solution fit the MAAS data satisfactorily. Reliability coefficients, including Cronbach's alpha, Guttman split-half, item–total correlations, and test–retest, were also satisfactory. Addressing validity, the MAAS was negatively correlated with PANAS negative affect and positively associated with PANAS positive affect as well as with the quality of life indexed by the WHOQOL-BREF. The Chinese version of the MAAS appears to be a reliable and valid instrument to assess levels of mindfulness in a Chinese college population.
This study examined the relationship between wandering mind, depression and mindfulness. We used the Sustained Attention to Response Task to assess the wandering mind, while the online thought probes were employed as the subjective marker for mind-wandering. The Beck Depression Inventory and Mindfulness Attention and Awareness Scale were used to assess depression and dispositional mindfulness respectively. The results revealed that the wandering mind even without awareness was not only positively associated with depression, but also negatively related to dispositional mindfulness. Depression was negatively related to dispositional mindfulness. These results might provide evidence that a wandering mind is positively associated with depression and mindfulness.