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The present study examined whether psychological inflexibility and mindfulness, 2 major emotion/behavior regulation processes, were uniquely and separately related to somatization, depression, and anxiety in a sample of Asian Americans in the United States. One hundred sixteen participants from various Asian nationality backgrounds completed a Web-based survey that included the measures of interest. Results revealed that both regulation processes were uniquely and separately related to somatization, depression, and anxiety after controlling for age and gender. Greater psychological inflexibility was associated with greater somatic, depressive, and anxiety symptoms, and greater mindfulness was associated with lower somatic, depressive, and anxiety problems. Our findings suggest that the extent to which one is unwilling to contact distressful internal and external experiences as well as the extent to which one is aware of the present-moment experience are useful concepts to understand somatization, depression, and anxiety experienced by Asian American young adults.