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Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (<i>1</i>-<i>7</i>), were newly isolated from a methanol extract of daisy, the flowers of <i>Bellis perennis</i> L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A-M (<i>8</i>-<i>20</i>), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (<i>2</i>, IC<sub>50</sub> = 11.2, 14.3, and 6.9 μM, respectively) showed relatively strong activities. The mechanism of action of <i>2</i> against HSC-2 was found to involve apoptotic cell death.