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The frontal lobes are responsible for many of the aspects of cognition that seem uniquely human, including aspects of planning, language, emotional control, and personality. Disorders of the frontal lobes take many forms, but ultimately their impact on our cognition and behavior depends on their location and how they disrupt normal neuronal functioning. This chapter reviews the neuroanatomy of the frontal lobes as relevant to movement, attention, memory, executive functioning, language, emotion, motivation, and social behavior. The disruptive influences of different neurological disorders illustrate the significance of frontal brain regions.