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Tibetan medicines are key material objects for medical treatment and have become part of a global trend of 'pharmaceuticalisation', playing increasingly important political and socio-economic roles in an 'alternative modernity'. As I argue in this paper, they also have become key 'sites of contestation' between different epistemic values and styles of practice related to efficacy and safety that are reproduced in and through specific formulation regimes. Based on my multisited ethnography of production, prescription, and use practices of Tibetan medicines in China and Europe, this paper conceptualises three distinct formulation regimes, offering a heuristic model for transnational comparison-a classical, an industrialised or reformulated, and a polyherbal regime. The first two are the major orientations while the polyherbal is a conjoint hybrid with either the classical or the industrialised formulation regime. Globalised national drug safety regulations legalise and confer legitimacy to industrialised Tibetan formulas that follow biomedically defined efficacy, safety, and disease categories, while classical formulas produced by private physicians or small-scale cottage pharmacies are increasingly marginalised as producing 'unsafe' and at times illegal medicines, and need to find new ways for adapting and circulating their formulas.;

Ethnopharmacological relevanceGeological materials, such as minerals, have a long history of usage as ingredients in multicompound formulations of Himalayan Sowa Rigpa medicine – as well as in its localized form of Bhutanese traditional medicine (BTM) – for treating various disorders for over thousand years. Yet, hardly any scientific research has been done on their ethnopharmacological efficacy and chemistry. Aim of the study This study documents and correlates the rarely explored ethnopharmacological and chemical identification of various minerals and their ethnomedicinal uses in BTM formulations for the first time. Material and methods A five stage cross-disciplinary process was conducted as follows: (1) a review of classical literature of Sowa Rigpa texts (Tibetan medical texts, pharmacopoeias and formularies) that are still in use today; (2) listing of mineral ingredients according to Sowa Rigpa names, followed by identification with common English and chemical names, as well as re-translating their ethnomedical uses; (3) cross-checking the chemical names and chemical composition of identified Sowa Rigpa minerals with various geological mineral databases and mineral handbooks; (4) authentication and standardization of Sowa Rigpa names through open forum discussion with diverse BTM practitioners; (5) further confirmation of the chemical names of identified minerals by consulting different experts and pharmacognosists. Results Our current study lists 120 minerals as described in Sowa Rigpa medical textbooks most of which we were able to chemically identify, and of which 28 are currently used in BTM herbo-mineral formulations. Out of these 28 mineral ingredients, 5 originate from precious metal and stone, 10 stem from earth, mud and rocks, 8 are salts, and 5 concern ‘essences’ and exudates. Conclusions Our study identified 120 mineral ingredients described in Sowa Rigpa medical textbooks, out of which 28 are currently used. They are crucial in formulating 108 multicompound prescription medicines in BTM presently in use for treating more than 135 biomedically defined ailments.

There is a growing interest in studies that document the relationship between science and medicine - as ideas, practices, technologies and outcomes - across cultural, national, geographic terrain. Tibetan medicine is not only known as a scholarly medical tradition among other Asian medical systems, with many centuries of technological, clinical, and pharmacological innovation; it also survives today as a complex medical resource across many Asian nations - from India and Bhutan to Mongolia, Tibet (TAR) and China, Buryatia - as well as in Western Europe and the Americas. The contributions to this volume explore, in equal measure, the impacts of western science and biomedicine on Tibetan grounds - i.e., among Tibetans across China, the Himalaya and exile communities as well as in relation to globalized Tibetan medicine - and the ways that local practices change how such “science” gets done, and how this continually hybridized medical knowledge is transmitted and put into practice. As such, this volume contributes to explorations into the bi-directional flows of medical knowledge and practice.

There is a growing interest in studies that document the relationship between science and medicine - as ideas, practices, technologies and outcomes - across cultural, national, geographic terrain. Tibetan medicine is not only known as a scholarly medical tradition among other Asian medical systems, with many centuries of technological, clinical, and pharmacological innovation; it also survives today as a complex medical resource across many Asian nations - from India and Bhutan to Mongolia, Tibet (TAR) and China, Buryatia - as well as in Western Europe and the Americas. The contributions to this volume explore, in equal measure, the impacts of western science and biomedicine on Tibetan grounds - i.e., among Tibetans across China, the Himalaya and exile communities as well as in relation to globalized Tibetan medicine - and the ways that local practices change how such "science" gets done, and how this continually hybridized medical knowledge is transmitted and put into practice. As such, this volume contributes to explorations into the bi-directional flows of medical knowledge and practice.

Tibetan medicine is recognized today as one of the world’s mostcomplex and sophisticated systems of medicine. Over the last 1300 years, Tibetan medical traditions have produced a vast corpus of literature analogous in complexity to the medical scholasticism of India, China, or Greece. Tibetan medical systems are practised widely today in the countries of Nepal, Bhutan, and Mongolia; in Tibetan populated areas of the People’s Republic of China; in parts of Russia (Kalmykia, Buryatia); and throughout India (Ladakh, Sikkim, and in Tibetan refugee settlements). The popularity and use of Tibetan medicine is growing in Europe, North America, and the Pacific Rim as well.

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