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This study examined the potential buffering role of trait mindfulness in the relationship between perceived discrimination and depressive symptoms in a community-based sample of racial and ethnic minority adults. Analyses conducted on 97 participants indicated that self-reported trait mindfulness moderated the relationship between perceived discrimination and depressive symptoms. Individuals low in mindfulness experienced elevated depressive symptoms at high levels of discrimination. However, individuals high in mindfulness reported lower depressive symptoms at high levels of discrimination. Results remained robust when controlling for potential confounding effects of age, sex, and income. Results suggest mindfulness is an important individual difference that may confer resilience for racial and ethnic minority communities who experience disproportionate levels of discrimination-related stressors and health disparities. Findings point to the potential utility of interventions that target mindfulness as a modifiable skill that can be used specifically to cope with discrimination. Socio-cultural considerations for the use of mindfulness-based approaches in racial and ethnic minority communities are discussed.