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BACKGROUND: The dramatic rise in the prevalence of obesity and type 2 diabetes mellitus (T2DM) is associated with increased mortality, morbidity as well as public health care expenses worldwide. Previous research suggests that yoga holds promise for obesity and T2DM management. OBJECTIVE: The objective of the present study was to assess the effect of intensive integrated approach of yoga therapy (IAYT) on body fat and body mass index (BMI) and resting metabolism in mid-life overweight patients with T2DM (BMI, Mean +/- SD, 27.05 +/- 4.51). MATERIALS AND METHODS: Twenty-four mid-life patients (6 females) with T2DM (Age, Mean +/- SD, 55.38 +/- 7.96 years) participated in the study and practiced IAYT for 7 days. The IAYT works at five layers of human existence (physical, vital, mental, intellectual and bliss) to bring positive health. The body fat and BMI and resting metabolism were recorded before and after IAYT using Karada Scan body composition monitor HBF-375 from Omron Healthcare Singapore PTE LTD. STATISTICAL ANALYSIS: SPSS-16 was used to analyze the data. Shapiro-Wilk test showed that the data was not normally distributed. Further, the Wilcoxon signed-ranks test was used to analyze the change in means of pre- and post-measurements. RESULTS: Data analysis showed that there was a significant decrease in body fat and BMI and resting metabolism (in all assessments, P < 0.001). CONCLUSION: The present study suggests that 7 days practice of IAYT has a great promise for the management of overweight in mid-life patients with T2DM. Additional well-designed studies are needed before a strong recommendation can be made.