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To predict the suitable distribution patterns of Lycium ruthenicum in the present and future under the background of climate change, and provide reference for the resources sustainable utilization and GAP standardized planting. The software of Maxent and ArcGis was used to predict the potential suitable regions and grades of L. ruthenicum in China based on the 149 distribution information, climate data of contemporary (1950-2000) and future (20-80 decade of 21 century), and considering of three greenhouse gaseous emission scenario. The results showed that:the suitable distribution regions of L. ruthenicum are mainly concentrated in Xinjiang, Qinghai, Gansu, Neimenggu, and Ningxia province in present. In addition, Shaanxi, Shanxi and Xizang are also distribution regions.The suitable distribution area of L. ruthenicum is 284.506 949×104 km2, accounted for 29.6% of the land area of China.The relatively stable area of the suitable regions accounted for 25.2% of the total suitable region area.Under the background of climate change, compared with contemporary, the total area of suitable region is reducing and moderately suitable area is increasing at different degree at the 20, 30, 40, 50, 60, 70, 80 decade of 21 century. Climate change both can change the total area of suitable regions and habitat suitability of L. ruthenicum. It could provide a strategic guidance for protection, development and utilization of L. ruthenicum though the prediction of potential suitable regions distribution of L. ruthenicum based on the mainly factor of climate change.

INTRODUCTION: Qigong exercise offers a potentially safe, low-cost and effective mind-body rehabilitative intervention for mitigating the problem of gait interruption among patients with Parkinson's disease (PD) who have frequent freezing of gait (FOG) episodes. However, its clinical effects have not been established. This paper describes the trial protocol of evaluating the clinical efficacy of a newly developed Integrated Qigong in improving gait among patients with PD who have FOG.METHODS AND ANALYSIS: A single-blind randomised controlled trial is designed to compare Integrated Qigong and balance training with an attention control. Participants will be patients with mild to moderate PD who experience FOG and are recruited from local communities in Shanghai, China. Participants will be randomly allocated to one of the three groups: Integrated Qigong group, a balance exercise intervention group, or control group. The total number of participants will be 126, and masked assessments will be made at baseline, 12 weeks (end of intervention) and 12-week follow-up. Both Integrated Qigong group and balance training group will receive a group-based exercise intervention that meets three times per week, 60 min in duration, for 12 weeks. The control group will receive a 60 min weekly group session and monthly health education. The primary outcomes are gait parameters (stride length, gait velocity, stride time variability) and occurrence of FOG. The secondary outcomes are postural instability, walking disability, falling, fear of falling and quality of life. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of Shanghai University of Sport and registered at China Clinical Trial Registry. Participants will sign informed consent prior to the participation of the trial. The findings of the study will be published in peer-reviewed academic journals and disseminated to PD support groups, medical community and media. TRIAL REGISTRATION NUMBER: ChiCTR1800016570.