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A simple, efficient and accurate liquid chromatographic method was established to determine five flavonoid aglycones, 7-hydroxy flavonone, pinocembrin, 2′,4′-dihydroxy chalcone, 2′-hydroxy-4′-methoxy chalcone and pinostrobin in the whole plant powder of <i>Oxytropis falcata</i> Bunge. These five compounds were separated on an Agilent Zorbax Eclipse XDB-C<sub>8</sub> column (150 × 4.6 mm, 5 μm). Mobile phases were composed of water containing 0.1% <i>v/v</i> formic acid and acetonitrile using gradient elution. The established method was validated for linearity, accuracy, precision, limit of detection and quantitation, repeatability and stability.
Objective: This study aimed to investigate effects of mindfulness-based stress reduction (MBSR) on anxiety, depression and quality of life in patients with intrauterine adhesion. Methods: Patients who received therapy for intrauterine adhesion (IUA) were recruited and randomized into MBSR group and Wait-List group (WL group). 71 women who received routine physical examination were recruited as healthy controls. Patients in MBSR group received MBSR training for 8 weeks. Results: There were 76 patients in MBSR group, 75 patients in WL group and 71 subjects in control group. When compared with control group, the scores of anxiety and depression increased significantly and the score of quality of life reduced significantly before intervention. In patients, the scores of quality of life in all the domains were negatively related to the scores of anxiety and depression (P<0.05). After MBSR for 8 weeks, there was a significant time and group interaction for the anxiety score (F=55.168, P<0.001) and depression score (F=252.485, P<0.001). The MBSR group showed a decrease in the anxiety and depression score, while the WL group did not. The quality of life (except for bodily pain) in the MBSR group was also significantly improved. The recurrence rate in the MBSR group was 18.4%, which was significantly lower than that in WL group (34.7%; P=0.024). Conclusion: IUA patients have evident anxiety and depression, which significantly reduces the life quality of patients. MBSR may improve the anxiety and depression of IUA patients during therapy, promote the post-operative recovery and improve their quality of life.
Objective: This study aimed to investigate effects of mindfulness-based stress reduction (MBSR) on anxiety, depression and quality of life in patients with intrauterine adhesion. Methods: Patients who received therapy for intrauterine adhesion (IUA) were recruited and randomized into MBSR group and Wait-List group (WL group). 71 women who received routine physical examination were recruited as healthy controls. Patients in MBSR group received MBSR training for 8 weeks. Results: There were 76 patients in MBSR group, 75 patients in WL group and 71 subjects in control group. When compared with control group, the scores of anxiety and depression increased significantly and the score of quality of life reduced significantly before intervention. In patients, the scores of quality of life in all the domains were negatively related to the scores of anxiety and depression (P<0.05). After MBSR for 8 weeks, there was a significant time and group interaction for the anxiety score (F=55.168, P<0.001) and depression score (F=252.485, P<0.001). The MBSR group showed a decrease in the anxiety and depression score, while the WL group did not. The quality of life (except for bodily pain) in the MBSR group was also significantly improved. The recurrence rate in the MBSR group was 18.4%, which was significantly lower than that in WL group (34.7%; P=0.024). Conclusion: IUA patients have evident anxiety and depression, which significantly reduces the life quality of patients. MBSR may improve the anxiety and depression of IUA patients during therapy, promote the post-operative recovery and improve their quality of life.
Objective: This study aimed to investigate effects of mindfulness-based stress reduction (MBSR) on anxiety, depression and quality of life in patients with intrauterine adhesion. Methods: Patients who received therapy for intrauterine adhesion (IUA) were recruited and randomized into MBSR group and Wait-List group (WL group). 71 women who received routine physical examination were recruited as healthy controls. Patients in MBSR group received MBSR training for 8 weeks. Results: There were 76 patients in MBSR group, 75 patients in WL group and 71 subjects in control group. When compared with control group, the scores of anxiety and depression increased significantly and the score of quality of life reduced significantly before intervention. In patients, the scores of quality of life in all the domains were negatively related to the scores of anxiety and depression (P<0.05). After MBSR for 8 weeks, there was a significant time and group interaction for the anxiety score (F=55.168, P<0.001) and depression score (F=252.485, P<0.001). The MBSR group showed a decrease in the anxiety and depression score, while the WL group did not. The quality of life (except for bodily pain) in the MBSR group was also significantly improved. The recurrence rate in the MBSR group was 18.4%, which was significantly lower than that in WL group (34.7%; P=0.024). Conclusion: IUA patients have evident anxiety and depression, which significantly reduces the life quality of patients. MBSR may improve the anxiety and depression of IUA patients during therapy, promote the post-operative recovery and improve their quality of life.
2′,4′-Dihydroxychalcone (TFC), one of the main components in Herba Oxytropis, belongs to the flavonoid group, which is known to have anti-tumor activity in vitro. In this study, the authors examined the effects of TFC on cell proliferation and apoptosis in human gastric cancer MGC-803 cells. The MTT assay results showed that TFC was able to induce cytotoxicity in MGC-803 cells in a concentration- and time-dependent manner. Acridine orange/ethidium bromide (AO/EB) staining analysis indicated that the cytotoxicity induced by TFC was mediated by apoptosis, and flow cytometry analysis indicated an increase in apoptotic cells after treatment with TFC. Furthermore, typical apoptotic morphology such as condensed chromatin, irregular nuclei, vacuoles, and dispersed granular material in the nuclear compartment were also observed using a transmission electron microscope. These results suggested that TFC can inhibit the growth of MGC-803 cells and induce apoptosis. However, further studies are necessary to investigate the possible mechanism.