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The article discusses hypoxic pathophysiology and high-altitude medicine as of December 2012, with a focus on the therapeutic effects of traditional Tibetan medicine Ratanasampil (RNSP) on β-amyloid (Aβ) pathologies and its potential role in Alzheimer's disease (AD) treatments. Topics include Aβ peptide production and its connection to chronic hypoxia, the use of AD transgenic mouse models, and C-terminal fragment (CTF) densitometry. Additional information is presented on the tumor necrosis factor (TNF).

"The ancient art of Tibetan medicine is a veritable treasure in the world annals of medical science. Tibetan medicine evolved over ages, as the Tibetan people accumulated experience struggling against the conditions of the snow plateau, emerging as a unique realm of medicine with a distinct understanding of physiology and pathology and its own methods of diagnosis, treatment and medication. The abundant medicinal herbs that grow on the plateau are the active ingredients in the special medicines Tibetans use to treat patients, which in turn is a precious cultural legacy that is now being passed on to the world. Known for its traditional therapies, Tibetan medicine is remarkably effective and beneficial, and has made great contributions to the overall health of humankind"--Container.