The purpose of present study was to examine the casualrelationship between mindfulness and perceived stress with mediating role of self-efficacy, emotional intelligence and personality traits among university students. The population in this study was all of the university students in Islamic Azad University of Zanjan, Iran. Who are studying in 2015-2016 academic year. From this population 250 students were selected using random stratified sampling method. The research instruments were Mindful Attention Awareness Scale (MAAS), Scherrer's self-efficacy questionnaire, The Schutte Self Report Emotional Intelligence Test (SSEIT), NEO Personality InventoryShort Form (NEO-FFI), and The Perceived Stress Scale (PSS). The proposed model of the relationships between variables was tested using structural equation modeling. According to results, proposed model had an acceptable fitness regarding fitness indices. Results revealed that there is relationship between mindfulness and perceived stress, with mediating role of self-efficacy, emotional intelligence and personality traits among university students.