The capacity for human service professionals to replenish resilience is important to their health and psychological wellbeing. The current study evaluated a brief Mindful Awareness and Resilience Skills Training (MARST) program designed to enhance mindfulness and positive re-appraisal as psychological mechanisms for increasing resilience, decreasing psychological distress and perceived stress. This program was informed by the Mindful-Cognitive Model of Cultivating Resilience. A sample of 46 human service professionals were randomly allocated to a MARST group or control group. Short term and follow-up training effects were examined using MANOVA. At post-training, the MARST group reported significantly higher levels of resilience, mindfulness and positive re-appraisal compared to the control group. At one-month follow-up, the MARST group reported significantly higher levels of resilience, mindfulness, and positive re-appraisal, and significantly lower levels of perceived stress and psychological distress relative to the control group. The findings provide preliminary support for the efficacy of the MARST program to increase resilience and decrease levels of psychological distress and perceived stress among human services professionals.