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The cyclic AMP phenotype of fragile X and autism
Neuroscience and Biobehavioral Reviews
Format: Journal Article
Pages: 1533-1543
Sources ID: 22834
Visibility: Public
Zotero Collections: Contexts of Contemplation Project
Abstract: (Show)
Cyclic AMP (cAMP) is a second messenger involved in many processes including mnemonic processing and anxiety. Memory deficits and anxiety are noted in the phenotype of fragile X (FX), the most common heritable cause of mental retardation and autism. Here we review reported observations of altered cAMP cascade function in FX and autism. Cyclic AMP is a potentially useful biochemical marker to distinguish autism comorbid with FX from autism per se and the cAMP cascade may be a viable therapeutic target for both FX and autism.
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