Administered the Comprehensive Scale of Stress Assessment: Part 1, Global Assessment, the Comprehensive Scale of Stress Assessment Symptom Checklist, and The Multiple Affect Adjective Checklist—Revised to assess dysphoria (anxiety, depression, and hostility), positive affect, and sensation seeking among 126 Ss (aged 25–50 yrs). Ss also indicated their frequency of meditation. Frequent meditators reported significantly fewer stressors and illness symptoms; lower levels of anxiety, hostility, depression, and dysphoria; and higher levels of positive affect and sensation seeking than did infrequent meditators. Frequent meditation was associated with reductions in the degree of correlation between stress and dysphoria, and between illness symptoms and dysphoria. Thus, for frequent meditators, increased stress and illness symptoms were not necessarily accompanied by increased negative affect.