Objective: The aim of the present study was to investigate the efficacy of mindfulness-based cognitive therapy (MBCT) on self-efficacy and anxiety among epileptic patients.Methods: The present study with a pretest-posttest control-group design was performed on epileptic patients in public healthcare centers of Kuhdasht, Iran. Through randomized sampling, 15 patients were selected for the experimental group and 15 epileptic patients for the control group. The experimental group received MBCT once a week during 8 sessions, while the control group was engaged in usual activities. The data collection tools included the general self-efficacy scale (GSES) and Zung self-rating anxiety scale (SAS). For statistical analysis, descriptive tests and repeated measures analysis of variance were performed. Results: Data analysis showed significant differences in self-efficacy and anxiety scores between the experimental and control groups (P < 0.001). Conclusions: According to the results, MBCT can increase self-efficacy and decrease anxiety in epileptic patients.