Workplace stress within health care settings is rampant and predicted to increase in coming years. The profound effects of workplace stress on the health and safety of nursing personnel and the financial impact on organizations are well documented. Although organizational modification can reduce some sources of stress, several unique stress-producing factors inherent in the work of nursing personnel are immutable to such approaches. Mindfulness training, an evidence-based approach to increase situational awareness and positive responses to stressful situations, is an inexpensive strategy to reduce stress and improve the quality of nurses' work lives. Several approaches to training, such as mindfulness-based stress reduction, can be tailored to health care settings. Considerations for occupational health nurses in incorporating mindfulness training as an aspect of a comprehensive work site health promotion program for nursing and other hospital personnel are discussed.