While the adverse impact of stress on health states has been established, effective stress reduction programs are largely underused in clinical settings. In an area with little published information, this study identifies themes that describe the process of applying mindfulness methods to cope with psychosocial stressors in participants of the Mindfulness-Based Stress Reduction (MBSR) program. The study design is a qualitative investigation with a phenomenological approach using participant feedback from 11 MBSR 8-week programs. Participants were 74 adults from the greater Pittsburgh area. Content analysis was used to inductively generate thematic categories. Four themes were identified that described the process and results of learning mindfulness to adapt to psychosocial stressors. We categorized participants’ feedback into interrelated themes of awareness (subdivided into self-discovery—“step back from my thoughts in order to view them more clearly”, and being in the present), coping—“pause, take a breath”, serenity—“increased feeling of calm, centeredness”, and change in perspective—“different understanding interpersonally and intrapersonally.” In addition, a brief section describes specific health benefits identified by participants. Participants found the mindfulness-based approach effective for stress reduction. The learning process allowed them to routinely apply mindfulness strategies that provided multiple benefits. (PsycINFO Database Record (c) 2016 APA, all rights reserved)