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Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013 – 2017).
PLoS ONE
Short Title: PLoS ONE
Format: Journal Article
Publication Date: 2018/09/18/
Pages: 1 - 12
Sources ID: 93771
Notes: Accession Number: 131827918; Kurskaya, Olga 1; Email Address: kurskaya_og@mail.ru Ryabichenko, Tatyana 2 Leonova, Natalya 3 Shi, Weifeng 4 Bi, Hongtao 5 Sharshov, Kirill 1 Kazachkova, Eugenia 1 Sobolev, Ivan 1 Prokopyeva, Elena 1 Kartseva, Tatiana 2 Alekseev, Alexander 1 Shestopalov, Alexander 1; Affiliation:  1: Department of Experimental Modeling and Pathogenesis of Infectious Diseases, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia  2: Department of Propaedeutic of Childhood Diseases, Novosibirsk State Medical University, Novosibirsk, Russia  3: Department of Children’s Diseases, Novosibirsk Children’s Municipal Clinical Hospital №6, Novosibirsk, Russia  4: Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, Shandong, China  5: Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, CAS, Xining, China; Source Info: 9/18/2018, Vol. 13 Issue 9, p1; Subject Term: RESPIRATORY infections in children; Subject Term: CHILD mortality; Subject Term: VIRUS diseases; Subject Term: CHILDREN; Subject Term: INFLUENZA transmission; Subject Term: REVERSE transcriptase polymerase chain reaction; Subject Term: DIAGNOSIS; Subject Term: RUSSIA; Author-Supplied Keyword: Age groups; Author-Supplied Keyword: Biology and life sciences; Author-Supplied Keyword: Children; Author-Supplied Keyword: Co-infections; Author-Supplied Keyword: Families; Author-Supplied Keyword: Infectious diseases; Author-Supplied Keyword: Influenza; Author-Supplied Keyword: Influenza A virus; Author-Supplied Keyword: Influenza viruses; Author-Supplied Keyword: Medical microbiology; Author-Supplied Keyword: Medicine and health sciences; Author-Supplied Keyword: Microbial pathogens; Author-Supplied Keyword: Microbiology; Author-Supplied Keyword: Organisms; Author-Supplied Keyword: Orthomyxoviruses; Author-Supplied Keyword: Paramyxoviruses; Author-Supplied Keyword: Pathogens; Author-Supplied Keyword: Pathology and laboratory medicine; Author-Supplied Keyword: People and places; Author-Supplied Keyword: Population groupings; Author-Supplied Keyword: Pulmonology; Author-Supplied Keyword: Research Article; Author-Supplied Keyword: Respiratory infections; Author-Supplied Keyword: Respiratory syncytial virus; Author-Supplied Keyword: RNA viruses; Author-Supplied Keyword: Viral diseases; Author-Supplied Keyword: Viral pathogens; Author-Supplied Keyword: Viruses; Number of Pages: 12p; Document Type: Article
Visibility: Public (group default)
Abstract: (Show)
Background: Acute respiratory infections (ARIs) cause a considerable morbidity and mortality worldwide especially in children. However, there are few studies of the etiological structure of ARIs in Russia. In this work, we analyzed the etiology of ARIs in children (0–15 years old) admitted to Novosibirsk Children’s Municipal Clinical Hospital in 2013–2017. Methods: We tested nasal and throat swabs of 1560 children with upper or lower respiratory infection for main respiratory viruses (influenza viruses A and B, parainfluenza virus types 1–4, respiratory syncytial virus, metapneumovirus, four human coronaviruses, rhinovirus, adenovirus and bocavirus) using a RT-PCR Kit. Results: We detected 1128 (72.3%) samples were positive for at least one virus. The most frequently detected pathogens were respiratory syncytial virus (358/1560, 23.0%), influenza virus (344/1560, 22.1%), and rhinovirus (235/1560, 15.1%). Viral co-infections were found in 163 out of the 1128 (14.5%) positive samples. We detected significant decrease of the respiratory syncytial virus-infection incidence in children with increasing age, while the reverse relationship was observed for influenza viruses. Conclusions: We evaluated the distribution of respiratory viruses in children with ARIs and showed the prevalence of respiratory syncytial virus and influenza virus in the etiological structure of infections. This study is important for the improvement and optimization of diagnostic tactics, control and prevention of the respiratory viral infections. [ABSTRACT FROM AUTHOR]