In this research we investigated the role of mindfulness-based attention in mitigating possible negative consequences of experiencing depressive affect. A sample of 278 undergraduate college students completed self-report measures of depressive affect, negative cognitions, and mindfulness-based attention. As expected, depressive affect was positively related to negative cognitions, mindfulness-based attention was inversely related to negative cognitions, and the strength of the relationship between depressed affect and negative cognitions was significantly moderated by mindfulness-based attention. More specifically, a simple slope analysis revealed that individuals low in mindfulness-based attention evidenced a statistically significant relationship between depressive affect and negative cognitions, whereas individuals who are high in mindfulness-based attention did not. These findings support the extant literature suggesting that the general tendency to be mindful may be a protective factor against the development of psychopathology and enhance mental health.