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Three new monoterpene glycosides from Sibiraea laevigata (L.) Maxim
PHYTOL Phytochemistry Letters
Format: Journal Article
Publication Date: Nov 30, 2016
Pages: 176 - 180
Sources ID: 104381
Visibility: Public (group default)
Abstract: (Show)

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• Three new monoterpene glycosides (1-3) were isolated from Sibiraea laevigata (L.) Maxim. • Fourteen known compounds (4-17) were also obtained from the title plant. • All of the isolated compounds were evaluated for their anti-oxidant and α-glucosidase inhibitory activities. • Compounds 7 and 17 exhibited α-glucosidase inhibitory effect with IC50 values of 220.0 and 113.0 μM, respectively.
Three new compounds, 3,7-dimethy-7-methoxy-3-octene-5-one-1-O-β-d-glucopyranoside (1), 3,7-dimethy-7-methoxy-3(Z)-octene-5-one-1-O-β-d-glucopyranoside (2) and 3,7-dimethy-3-hydroxy-6-octene-5-one-1-O-β-d-glucopyranoside (3), together with fourteen known compounds (4-17) were isolated from the leaves and shoots of S. laevigata. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including one- and two-dimensional NMR, as well as mass spectral data. All isolates were evaluated for their α-glucosidase inhibitory and antioxidant activities. The results demonstrated that 3,7-dimethyl-3(Z),6-ocatdien-5-one-1-O-β-d-glucoside (7) and sitosteryl β-d-glucoside (17) exhibited α-glucosidase inhibitory effects with IC50 values of 220.0 and 113.0 μM, respectively.